Aspergillus pneumonia and meningitis in a patient with lupus nephritis: case report and literature review
10.3760/cma.j.issn.1001-7097.2011.10.008
- VernacularTitle:狼疮肾炎并发肺部曲霉菌感染及脑膜炎一例暨文献复习
- Author:
Xin WANG
;
Wei CHEN
;
Zongpei JIANG
;
Xueqing YU
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
Invasive fungal infection;
Aspergillus;
Cryptococcns neoformans
- From:
Chinese Journal of Nephrology
2011;27(10):740-745
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveByreportinga fatalcaseof severelupusnephritis(LN) complicated with invasive aspergilluspneumonia and meningitis and reviewing the associated literatures,to provide a way of early diagnosis andproper management for the patients suffering from systemic lupus erythematosus(SLE) and invasive fungus infection(IFI).MethodsThe onset,diagnosis and treatment course of the disease were described and associated literatures werereviewed to analyze and summary the diagnostic methods,common pathogenic bacteria and predisposing factors of SLE patients with IFI.ResultsApplication of IFI guideline for cancer patients and those undergoing hematopoietic stem cell transplantation could be helpful in the early diagnosis and treatment of SLE patients complicated with IFI.The most common pathogen of SLE patient suffering from IFI was cryptococcus neoformans and aspergillus,not candida albicans.The mainpredisposingfactorswerehighlupusactivityandimmunosuppressant.Conclusions Guideline of IFI for cancer patients and those undergoing hematopoietic stem cell transplantation is also helpful for the SLE patients complicated with IFI.The most common pathogens of IFI in SLE patients are cryptococcusneoformansand aspergillus.The predisposing factors are high lupus activity and immunosuppressant.
