Value of amplitude-integrated EEG in predicting neurodevelopmental outcome of full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis
10.3760/cma.j.issn.1007-9408.2011.11.004
- VernacularTitle:振幅整合脑电图预测足月儿缺氧缺血性脑病预后的meta分析
- Author:
Guoqiang CHENG
;
Lixia CHEN
;
Xiaomei SHAO
;
Wenhao ZHOU
- Publication Type:Journal Article
- Keywords:
Hypoxia-ischemia,brain;
Electroencephalography;
Infant,newborn;
Prognosis;
Meta-analysis
- From:
Chinese Journal of Perinatal Medicine
2011;14(11):653-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of amplitude-integrated EEG(aEEG)as a quantitative predictor of neurodevelopment outcome of full-term infants with hypoxic-ischemic encephalopathy(HIE).Method EMBASE,Ovid,PubMed,Cochrane Library,Springer Database,CNKI,CSJD and Wanfang Database were searched from when the database was founded to June 30,2010 for studies about aEEG as a predictor of neurodevelopment outcome in full-term infants with HIE.Characteristic information of each articles was extracted and QUADAS items were used to evaluate the qualities of included studies.Meta-disc software 1.4 was used to perform the metaanalysis.All included studies were combined with weighted quantity; sensitivity,specificity,positive likelihood ratio,negative likelihood ratio and their 95 ％ CI were calculated.Results Eleven studies were eligible for the primary meta-analysis and totally 717 subjects were included.There was an overall sensitivity of 86％(95％ CI:81％-89％),specificity of 90％(95％ CI:86％-93％),positive likelihood ratio of 7.70(95％ CI:5.69-10.43),negative likelihood ratio of 0.17(95％ CI:0.13-0.22)and the area under the curve(AUC)of summary receiver operating characteristic curve was 0.95 for aEEG tracings to accurately predict poor outcome of HIE in full term neonates.Conclusion aEEG is a valuable bedside tool for predicting long-term neurodevelopment outcome in term infants with HIE.
