Expression and clinical pathological significance of CXCR4 and HIF-1α protein in esophageal squamous cell carcinoma
10.3760/cma.j.issn.1006-9801.2011.11.015
- VernacularTitle:食管鳞状细胞癌中趋化因子及其受体和缺氧诱导因子-1α蛋白的表达及其临床病理意义
- Author:
Min ZHAO
;
Min ZHAO
;
Hongbin ZHANG
;
Sumin GUO
;
Aili ZHENG
;
Xiangcun LIANG
;
Hongmei CAI
;
Jian LIANG
- Publication Type:Journal Article
- Keywords:
Esophageal cancer;
Chemokine receptor;
Hypoxia inducible factor 1alpha;
Immunohistochemistry
- From:
Cancer Research and Clinic
2011;23(11):772-774
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinicopathological significance of CXCR4 and HIF-1α protein in esophageal squamous cell carcinoma tissue and explore their correlation.Methods The expression of CXCR4 and HIF-1α protein were assessed by immunohistochemistry SP method in 56 cases with esophageal squamous cell carcinoma and in 20 cases with surrounded normal tissue.Results The expressions of CXCR4 and HIF-lα in esophageal squamous cell carcinoma were significantly higher than those in normal tissues[62.50 ％ (35/56) vs 10.00 ％ (2/20); 57.14 ％ (32/56) vs 0(0/20)](x2=16.259,19.740,P ＜0.01).The expression of CXCR4 and HIF-1α were both correlated with invasion depth (x2 =4.736,7.665,P ＜0.05) and lymph node metastasis ( x2 =7.207,6.389,P ＜0.05),and had no correlation with cancer cell differentiation.The expressions of CXCR4 and HIF-lα in esophageal squamous cell carcinoma were positively correlated (r =0.298,P ＜0.05).Conclusion CXCR4 and HIF-1α are highly expressed in esophageal squamous cell carcinoma.The two have a close relation to esophageal squamous cell carcinoma growth,invasion and metastasis.
