The effect of hepatitis B virus on the expression of high sensitive C-reaction protein and its clinical implication
10.3760/cma.j.issn.0254-5101.2011.10.019
- VernacularTitle:乙型肝炎病毒对超敏C反应蛋白表达的影响及其临床意义
- Author:
Guosheng GAO
;
Haichao ZHU
;
Airong HU
;
Xiaozhen XU
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
High sensitive C-reaction protein;
Liver cirrhosis;
Hepatocellular carcinoma
- From:
Chinese Journal of Microbiology and Immunology
2011;31(10):931-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of hepatitis B virus(HBV) on the expression of high sensitive C-reaction protein(hs-CRP) and its clinical implication.Methods mRNA expression of hs-CRP in HepG2 and HepG2.2.15 cells was measured by RT-PCR,serum hs-CRP levels in patients with HBV infection and in healthy individuals were measured by biochemical analyzer Olympus5400,the expression of hs-CRP difference among patients with chronic hepatitis B,liver cirrhosis and hepatocellular carcinoma were analyzed.Results Expression of hs-CRP mRNA was higher in HepG2.2.15 cells than in HepG2 cells,serum hs-CRP levels was much higher in HBV patients as compared to healthy individuals ( P＜0.05 ),hs-CRP was detected at higher levels in patients with liver cirrhosis or hepatocellular carcinoma than those with chronic hepatitis B.Conclusion HBV can upregulated the expression of hs-CRP,which is associated with the disease progression.
