Investigaiton on the invitro binding of RS-chlorpheniramine to human plasma proteins
- Author:
Bui Tung Hiep
- Publication Type:Journal Article
- Keywords:
Chlorpheniramine
- MeSH:
Chlorpheniramine;
Blood Proteins
- From:Pharmaceutical Journal
2005;0(1):18-22
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Isomeric selectivity of chlorpheniramine in period of binding to protein was demonstrated on serum, plasma used anticoagulant agent citrate- phosphate- dextrose (CPD) anticoagulant agent, albumin solution and refined α- glycoprotein acid solution. The binding rate to protein of optical isomer S(+)-chlorpheniramine is always higher than R(-)-chlorpheniramine with total serum protein (38% vs. 23%), total plasma protein (26% vs. 23%), albumin (20% vs. 15%) and α- glycoprotein acid (23% vs. 5%)
