Association between aquaporins expression in kidney tissue and edema of nephrotic syndrome patients
10.3760/cma.j.issn.1001-7097.2011.10.006
- VernacularTitle:肾组织水通道蛋白表达与肾病综合征水肿的关系
- Author:
Peng LI
;
Jianying NIU
;
Qi ZHANG
;
Weifeng FAN
;
Lihong LUO
;
Yingjun QIAN
;
Lihong ZHANG
;
Yong GU
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
Edema;
Aquaporins
- From:
Chinese Journal of Nephrology
2011;27(10):735-739
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo elucidate the association between aquaporins (AQPs) expression in kidney tissue and edema of nephrotic syndrome(NS) patients.MethodsNS patients were divided into edema group (14 cases) and non-edema group (8 cases).Ten patients without NS were used as control group.Expressions of AQP1,AQP2,and AQP4 in renal tissues of 3 groups were detectedbyimmunohistochemistrywithstandardtechniquesandsemi-quantitativeanalysis.Association between AQPs expression and edema was examined.ResultsThe positive index of AQP1 expression in proximal tubules in edema group was 0.0373±0.0110,which was significantly lower as compared to non-edema group (0.0510±0.0120) and control group 0.0574±0.0100),while the difference between non-edema and control groups was not significant.The positive index of AQP1 expression in glomerulus was 0.0106±0.0037 in edema group,which was significantly higher than that in non-edema group(0.0021±0.0013) and control group(0.0020±0.0012),while no significant difference was found between the last two groups.AQP2 mainly localized in the collecting duct system.The positive indexes of AQP2 expression were 0.0498±0.0081,0.0370± 0.0072 and 0.0255±0.0103 in edema group,non-edema group and control group,respectively.The differences were significant among 3 groups.AQP4 expression was not found in the renal cortex and collecting duct system.ConclusionsAQPs expression is different in renal tissues of NS patients.AQP2 may play an important role in the edema of NS patients,and AQP1 may involve in the occurrence of edema.
