Effects of trypsin inhibitors on Wnt signaling pathway and cellular apoptosis
10.3760/cma.j.issn.1006-9801.2011.10.029
- VernacularTitle:胰蛋白酶抑制剂对Wnt信号通路和细胞凋亡的作用
- Author:
Yarui ZHAO
;
Zongwei LI
;
Xinghua WANG
;
Zhuoyu LI
- Publication Type:Journal Article
- Keywords:
Trypsin inhibitors;
Signal transduction;
Apoptosis
- From:
Cancer Research and Clinic
2011;23(10):718-720
- CountryChina
- Language:Chinese
-
Abstract:
The trypsin inhibitor is a kind of substance that can inhibit trypsin activity.It shares extensive physiological roles.The trypsin inhibitor not only inhibits the activities of many enzymes,but also has significant anti-cancer effects by suppressing cell invasion and promoting cell apoptosis.Wnt signaling pathway involves in the regulation of cell growth,proliferation and apoptosis.It also plays an important role in tumor development.This review focuses on the impacts of trypsin inhibitors on Wnt signaling pathway and tumor cell apoptosis.
