The preliminary study of the value of MMP9, MPO and sCD40L in detection of the characteristics of coronary artery plaque
10.3760/cma.j.issn.1009-9158.2011.10.005
- VernacularTitle:血清MMP9和MPO及sCD40L识别冠状动脉斑块性质的初步研究
- Author:
Na JING
;
Bin Lü
;
Jinsuo KANG
;
Chunling ZHANG
;
Jinguo LU
;
Li ZHANG
;
Xiongbiao CHEN
;
Zhihui HOU
;
Xi CHEN
;
Xiangfeng CONG
- Publication Type:Journal Article
- Keywords:
Coronary artery disease;
Matrix metalloproteinase 9;
Peroxidase;
CD40 ligand;
Tomography,spiral computed
- From:
Chinese Journal of Laboratory Medicine
2011;34(10):889-892
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the utility of MMP9,MPO and sCD40L in detection of the character of coronary artery plaque.Methods From April 2008 to January 2010,118 patients from outpatient of Fu Wai Hospital with chest pain were enrolled.All of them underwent 64 Multiple-detector row spiral computer tomography (64-MDCT),the CT value ＜ 130 Hu patients were enrolled in non-calcified plaque group (71 cases),CT value ≥ 130 Hu patients were enrolled in the calcified plaque group (47 cases).Ninty healthy volunteers were selected as the control group.Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of serum markers,including MMP9,MPO and sCD40L.Levels of MMP9,MPO and sCD40L of each group were compared.ROC curve was used to evaluate the sensitivity and specificity of the markers in diagnosis of non-calcified plaque.Results MMP9,MPO and sCD40L levels of non-calcified were ( 762.25 ± 368.71 ),[ 844.10 (582.00 - 1220.70) ],(9.37 ± 3.15) μg/L,higher than the healthy control group (342.70 ± 178.53),[426.35 ( 283.20 - 592.00) ],(6.55 ± 2.96) μg/L and calcified plaque group ( 483.12 ± 219.09 ),[ 469.00 ( 302.45 - 723.55) ],( 7.24 ± 2.86) μg/L The difference was statistically significant ( F =42.47,H =50.28,F =17.94,all P ＜ 0.01 ). Areas of MMP9,MPO and sCD40L under the ROC curve to predict non-calcified plaque were 0.854,0.792,0.751 respectively,when the identification threshold for non-calcified plaque were 510.13,537.82,7.05 μg/L respectively,the diagnostic sensitivity was 80％,80％,80％ respectively,and specificity was 80％,67％ and 55％ respectively.Conclusion The serum MMP9,MPO and sCD40L levels can help to determine the character of coronary plaque.
