Effect of different time neoadjuvant hormornal therapy for locally advanced prostate cancer
10.3760/cma.j.issn.1006-9801.2011.10.011
- VernacularTitle:不同时间新辅助内分泌疗法对局部晚期前列腺癌疗效的影响
- Author:
Ruipeng HOU
;
Jian LI
;
Fengwei WANG
;
Zhihua ZHANG
;
Hao WEI
;
Tao TANG
;
Hua ZHANG
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Prostate-specific antigen;
Locally advanced;
Neoadjuvant hormomal therapy
- From:
Cancer Research and Clinic
2011;23(10):684-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate ideal solution of neoadjuvant hormomal therapy (NHT) for locally advanced prostate cancer.Methods 60 patients diagnosed with locally advanced (T3-4N0M0) prostate cancer were treated with NHT.They were randomly divided into 3 groups of 20 cases.A group:NHT 2 weeks,B group:NHT 3 months,C group:NHT 6 months.Results The median PSA of A,B and C group after NHT were 24.88 (6.62-55.86),0.20 (0.05-12.07) and 0.07 (0.01-2.01) ng/ml,respectively.There was statistically significance compared with those in untreatment ( all P =0.00).There was statistically significant (P =0.00)among groups.The prostate volume of A,B and C group were (49.50+14.19),(47.35±17.99) and (36.15±7.17)ml,respectively.There was statistically significance in the B and C group compared with that in untreatment (P =0.04,0.00).There was statistically significant between A and C group and between B and C group (P =0.00,0.01).The Qmax of A,B and C group were (8.75±2.15),(11.7±2.81) and (14.45±2.61) ml/s,respectively.There was statistically significance in the B and C group compared with untreatment (both P =0.00).There was statistically significance among groups (all P =0.00).Conclusion The NHT time should last at least 3 months in order to reduce PSA and prostate volume and to increase the Qmax.
