Efficacy of imipenem-cilastin sodium as subsequent therapy on peritoneal dialysis-related peritioniets
10.3760/cma.j.issn.1001-7097.2011.09.006
- VernacularTitle:亚胺培南-西司他丁钠在腹膜透析相关腹膜炎后续治疗的疗效
- Author:
Junbao SHI
;
Jiandong NIE
;
Linghua SUN
;
Gang FU
;
Qingfeng HAN
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Peritonitis;
Imipenem;
Cilastin sodium
- From:
Chinese Journal of Nephrology
2011;27(9):652-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of imipenem-cilastin sodium as subsequent therapy on peritoneal dialysis(PD)-related peritonitis.Methods From January 2007 to December 2010,44 PD-related peritonitis patients in our hospital were enrolled in the study.These patients presented cloudy fluid after 3 days initial treatment,and bacterial culture was Gram-negative bacteria or negative.Thirteen peritonitis episodes were treated with ceftazidime,while 36 episodes with imipenem-cilastin sodium.Efficacy,outcome,pathogen and drug-resistance were analyzed retrospectively.Results The effective rates 2 d later of ceftazidime and imipenem-cilastin sodium were 23.1％ and 72.2％ respectively with significant difference (P＜0.05).Gram-negative bacteria of ceftazidime and imipenem-cilastin sodium groups were 69.4％ and 65.2％ respectively without significant difference (P＞0.05).The cure rates 3 weeks later of ceftazidime and imipenemcilastin sodium groups were 23.1％ and 72.2％ respectively with significant difference (P＜0.05).Conclusion As subsequent therapy for PD-related peritonitis,imipenem-cilastin sodium can improve the cure rate.
