Expression and clinical significance of leptin in esophageal squamous cell carcinoma

VernacularTitle:瘦素在食管鳞状细胞癌中的表达及其临床意义
Author: Shanbing WANG ; Chunli WANG ; Shuangping ZHANG
Publication Type:Journal Article
Keywords: Leptin; Body mass index; Esophageal neoplasms; Neoplasms,squamous cell
From: Cancer Research and Clinic 2011;23(11):759-761
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship of serum leptin concentration,body mass index (BMI) and esophageal squamous cell carcinoma.Methods Blood samples were collected from 47 patients with esophageal squamous cell carcinoma and 20 healthy controls in Shanxi Cancer Hospital.Serum leptin was measured by ELISA.Results Serum leptin concentration in patients group was significantly higher than control group[(13.09±5.94) ng/ml vs (7.58±4.16) ng/ml,(t =3.76,P =0.001)].In 47 patients,BMI,albumin and lymphocytes were (25.20±3.14) kg/m2,(43.58±2.15) g/L and (2.02±0.55)×109/L,respectively.The serum leptin concentration of all patients (47 cases) were positive correlation with BMI (r =0.561,P =0.006),not with blood albumin and lymphocytes (r =0.206,P =0.242; r =0.122,P =0.412).Multiple logistic regressionanalysis reveal statistically significant association between serum leptin and esophageal squamous cell carcinoma incidence (OR =1.442,95 ％ CI 1.094-1.848,P=0.09).Conclusion Higher serum leptin levels seem to represent an additional and independent risk factor for esophageal squamous cell carcinoma.