Syphilid Showing a Histological Pattern of Granulomatous Inflammation.
- Author:
Eun Kyung KIM
1
;
Kyung Eun JUNG
;
Hei Sung KIM
;
Jun Young LEE
;
Hyung Ok KIM
;
Young Min PARK
Author Information
1. Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. yymmpark6301@hotmail.com
- Publication Type:Case Report
- Keywords:
Granulomatous inflammation;
Syphilid
- MeSH:
Arm;
Biopsy;
Dermis;
Diagnosis, Differential;
Endothelial Cells;
Ethylenediamines;
Giant Cells;
Humans;
Inflammation;
Lymphocytes;
Male;
Middle Aged;
Penicillin G Benzathine;
Plasma Cells;
Scalp;
Serologic Tests;
Skin;
Skin Diseases;
Syphilis;
Syphilis, Cutaneous
- From:Korean Journal of Dermatology
2012;50(8):730-733
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Syphilid represents a great variety of clinical and histological patterns. As such, sometimes it is difficult to make a differential diagnosis from other skin diseases. The histopathologic findings of syphilid are different, according to the clinical types; macular, maculopapular, papulosquamous, and nodular type. Characteristically, there is a marked perivascular infiltration of plasma cells and lymphocytes with endothelial cell swelling in the dermis. Herein, we report a case of syphilid showing the unusual histological pattern of granulomatous inflammation. A 45-year-old male presented with erythematous papules on the scalp, trunk, arms and inguinal area for 2 months. The biopsy specimen showed a chronic granulomatous inflammation with multinucleated giant cells in the dermis. Serologic test for syphilis showed a strong positive, and the patient was diagnosed with secondary syphilis. He was treated with benzathine penicillin G and the skin lesions have successfully disappeared.
