Diagnostic value of EUS-FNA for pancreatic masses and its influential factors
10.3760/cma.j.issn.1007-5232.2011.09.005
- VernacularTitle:内镜超声引导下细针穿刺抽吸术对胰腺占位病变诊断价值及其影响因素的研究
- Author:
Yi ZHANG
;
Qi ZHU
;
Tingting GONG
;
Xi CHEN
;
Junwei WU
;
Jia HUANG
;
Yunwei SUN
;
Jihong TAN
;
Lu XIA
;
Wei WU
- Publication Type:Journal Article
- Keywords:
Endoscopic ultrasonography;
Pancreas;
Diagnosis;
Fine needle aspiration
- From:
Chinese Journal of Digestive Endoscopy
2011;28(9):492-496
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the diagnostic value of EUS-FNA for pancreatic masses and correlated influential factors. MethodsWe retrospectively analyzed the clinical data of 101 patients with pancreatic lesions who underwent EUS-FNA from January 2008 to January 2010. The clinical data enrolled 10 factors including patient gender, patient age, lesion location, lesion size, lesion characteristics, negative suction pressure, times of access, real-time cytological diagnosis, type of EUS and operators' experiences.ResultsThe overall diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive value of EUS-FNA were 85. 1％, 81.1％, 96. 3％, 98. 4％ and 65.0％, respectively. Univariable logistic regression analysis indicated that lesion size, lesion characteristics, negative suction pressure, operators' experience were correlated factors of EUS-FNA positive rate, while lesion size was the only correlated factor of EUS-FNA diagnostic accuracy ( OR =1. 984,95 ％ CI: 1. 141 ～ 3. 451, P =0. 015 ). Every 1 cm the lesion increased, by 1.67 times of opportunity the positive rate became, by 1.83 times of opportunity the accuracy was. The lesion size and lesion characteristics were independent correlated factors of EUS-FNA positive rate (OR=2.012, P=0.000; OR =10.218, P=0. 002). The positive rate of EUS-FNA in solid lesions was 10. 2 times of that in cystic lesions. Lesion size was the independent correlated factors of EUS-FNA diagnostic accuracy (OR =1. 984, P =0. 015 ). ConclusionEUS-FNA can effectively make a pathological diagnosis of pancreatic masses with high diagnostic accuracy and specificity. EUS-FNA diagnostic positive rate and accuracy were both positively correlated with pancreatic lesion size. EUS-FNA positive rate of solid pancreatic lesions is significantly higher than that of cystic lesions.
