Expression and significance of NDRG1, p53 and VEGF in esophageal squamous cell carcinoma
10.3760/cma.j.issn.1006-9801.2011.09.012
- VernacularTitle:N-myc下游调节基因-1、p53和血管内皮生长因子在食管鳞状细胞癌组织中表达的意义
- Author:
Jiandan ZHANG
;
Qiong WANG
;
Zhijian ZHU
;
Yifan HUANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
NDRG1;
Gene,p53;
VEGF;
Immunohistochemistry
- From:
Cancer Research and Clinic
2011;23(9):613-616
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expression and significance of NDRG1(N-myc downstream regulated gene-1), p53 and VEGF in esophageal squamous cell carcinoma (ESCC). MethodsNDRG1, p53 and VEGF protein were detected by immunohistochemistry (IHC, SP method) in 20 cases of normal esophageal squamous epithelium and 78 cases of ESCC.ResultsThe results of IHC shows that in normal esophageal squamous epithelium and esophageal squamous cell carcinoma,the positive rate of NDRG1 was 100.0 ％(20/20) and 55.1％ (43/78) respectively, p53 was 0 (0/20) and 65.4 ％ (51/78) respectively, VEGF was 30.0 ％(6/20)and 67.9 ％(53/78)respectively,all had statistical significance.There was inverse correlationof NDRG1 expression and lymphatic invasion(r =-0.237,P = 0.036).However expression of NDRG1 was no statistical significance with patient' s age,gender,grade,TNM stage,patient' s five year survival.The expression of p53 was inverse correlated with NDRG1,and the expression of VEGF was inverse correlated with NDRG1 (r =-0.331, P = 0.003). ConclusionNDRG1 may be a new tumor suppress gene and play an important role in the development and metastasis of ESCC.
