Toxicity and telomerase activity of allicin combined with TFP chemotherapy for patients with advanced gastric carcinoma
10.3760/cma.j.issn.1006-9801.2011.09.013
- VernacularTitle:大蒜素联合TFP方案治疗晚期胃癌的毒副作用及对端粒酶活性的影响
- Author:
Li SUN
;
Sanyuan SUN
;
Ling WEI
;
Susheng CAO
;
Dahai YU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Allicin;
Telomerase;
Drug therapy,combination
- From:
Cancer Research and Clinic
2011;23(9):617-619
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveObserve the efficacy, toxicity and the effection of telomerase activity of allicin combined with paclitaxel plus cisplatin and 5-Fu(TFP)chemotherapy for patients with advanced gastric carcinoma.MethodsFifty-four patients with advanced gastric carcinoma were randomly divided into two groups. A group was treated with allicin and TFP, B group was only treated with TFP. The chemotherapy was paclitaxel (135 mg/m2, dl, 8) plus cisplatin (75 mg/m2, d2-4) followed by 5-Fu (500 mg/m2 d1-5). Allicin was used in 60 days(3 times every day,once 20 mg).Telomerase activity was performed by enzyme-linked immunosorbent assay. ResultsThe total efficiency rate was 40.7 ％ (11/27) in A group and 33.3 ％ (9/27) in B group.There was no statistical difference between the two groups(~ = 0.079,P =0.779).There was significant difference in nausea and vomit (P =0.043), and the incidence of A group was 77.8 ％ (21/27) which was lower than that of B group[92.6 ％(25/27)].There was statistical difference in telomerase activity between the two groups(P =0.000).ConclusionAllicin could reduce the toxicity of chemotherapy and inhibit the telomerase activity in advanced gastric carcinoma.
