Association analysis of two polymorphisms on chromosome 12p13 to cerebral infarction
10.3760/cma.J.issn.1006-7876.2011.09.010
- VernacularTitle:染色体12p13两基因间多态与脑梗死的关系
- Author:
Xianjin SHANG
;
Yi LIN
;
Ling FANG
;
Bin CAI
;
Wei WEI
;
Ning. WANG
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Atherosclerosis;
Polymorphism, single nucleotide;
Chromosomes,human,pair 12;
Cell adhesion molecules,neuronal;
Protein-serine-threonine kinases;
Genotype
- From:
Chinese Journal of Neurology
2011;44(9):613-618
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association of single nucleotide polymorphisms (SNPs)of rs11833579 and rs12425791 on chromosome 12pl3 with cerebral infarction in the Fujian Han population.MethodsA case-control association study containing a total of 216 cases and 279 controls was carried out.The genotypes of two polymorphisms were evaluated by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct DNA sequencing followed by association analysis.Results The frequency of G ＞ A genotype of rs12425791 in patients with cerebral infarction was lower than that in the controls (34. 3％ vs 43.4％ , x2 = 4. 298 ,P ＜ 0. 05 ) after stratified by causes of cerebral infarction, there was no significant difference in this genotype between large-artery atherosclerosis and controls.Association analysis was performed by logistic regression model after adjusting by sex, age, hypertension, diabetes mellitus, dyslipidemia, smoking and drinking. Rs12425791 G ＞ A genotype was significantly associated with both cerebral infarction ( OR = 0. 627, 95％ CI 0. 417-0. 941, P = 0. 024 ) and large-artery atherosclerosis ( OR =0. 613, 95％ CI 0. 396-0. 949 ,P =0. 028). G ＞ A genotype might be a potential protective factor in male( OR =0. 597, 95％ CI 0. 364-0. 978, P =0. 041 ). rs11833579 G ＞ A genotype frequency was similar between cases and controls.Conclusion rs12425791 G ＞ A on chromosome 12p13 might be a genetic marker for atherothrombotic brain infarction in Han population of Fujian.
