Vogt-Koyanagi-Harada syndrome: 5 cases report with clinical and neuroimaging features

VernacularTitle:Vogt-小柳-原田综合征五例临床及神经影像学特点
Author: Tao HAN ; Xue WANG ; Rui CHENG ; Yuxiang HAN ; Aiqin WANG ; Mingzhu MENG ; Shengjun WANG ; Xiuhe ZHAO ; Wei WU ; Lili CAO ; Zhaofu CHI ; Xuewu LIU
Publication Type:Journal Article
Keywords: Uveomeningoencephalitic syndrome; Magnetic resonance imaging; Melanophores
From: Chinese Journal of Neurology 2011;44(9):623-626
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical and neuroimaging features of Vogt-KoyanagiHarada syndrome ( VKH ).Methods Cerebrospinal fluid ( CSF ), neuroimaging examination, clinical manifestation and pharmacotherapy features were investigated in 5 patients diagnosed as VKH. ResultsAll 5 patients were diagnosed as uveitis in the early stage of disease.All patients suffered “ headache”.Meningeal irritation sign was appeared in 3 cases. The MRI enhanced scan of all 5 cases showed abnormal enhancement of meninges. CSF examination showed increased leukocyte number ((4--196) × 106/L). All patients were alleviatedwith combination therapyof high dose of steroid with cyclophosphamide.ConclusionsVKH is a systemic disease that usually involving the uvea, central nervous system, internal ear and the skin. MRI and CSF examination are valuable for diagnosis. High dose of steroid combined with cyclophosphamide is an effective therapeutic strategy.