Effects of drainage with vacuum and closure on acute wounds
10.3760/cma.j.issn.0254-1424.2011.08.005
- VernacularTitle:封闭式负压引流技术对兔急性创面愈合的影响
- Author:
Keke WANG
;
Jianghui LIU
;
Yong HUANG
;
Jiahua PENG
;
Weiping WANG
- Publication Type:Journal Article
- Keywords:
Drainage with vacuum and closure;
Wounds;
Connexin 43
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2011;33(8):579-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of drainage with vacuum and closure (VAC) on acute wounds, and explore the mechanism of drainage with VAC in promoting wound healing.Methods Twenty-four acute wounds were inflicted on the backs of 12 New Zealand white rabbits (each rabbit two wounds), and the rabbits were divided into a drainage with VAC group and a control group randomly. The drainage with VAC group was treated with drainage with VAC. The control group was treated with wet saline gauze. The wounds were observed 3 and 7 days after treatment. Patho-morphological changes in tissues from the compressed area were observed by HE staining. The expression level of Cx 43 mRNA was detected using a RT-PCR.Results At the 3rd and 7th day after treatment, the wounds of the drainage with VAC group were clean, fresh and had less edema compared with those of the control group. Pathomorphological tissue changes were more obvious in the drainage with VAC group. The expression of Cx 43 mRNA in the drainage with VAC group had declined significantly compared with the control group.Conclusion Drainage with VAC can promote inflammatory cell infiltration, down-regulate the expression of Cx 43 mRNA, and promote wound healing.
