Progress in single nucleotide polymorphism with cancer susceptibility and its clinical application
10.3760/cma.j.issn.1009-9158.2012.07.002
- VernacularTitle:单核苷酸多态性在肿瘤易感性及临床应用中的研究进展
- Author:
Chunling LIU
;
Dianke YU
;
Dongxin LIN
- Publication Type:Journal Article
- Keywords:
Single nucleotide polymorphisms;
Candidate gene;
Genome-wide association studies;
Exome sequencing;
Clinical application
- From:
Chinese Journal of Laboratory Medicine
2012;35(7):579-584
- CountryChina
- Language:Chinese
-
Abstract:
Single nueleotide polymorphisms (SNPs) are the most common genetic variants in human genome.Candidate gene,genome-wide association studies (GWASs) and exome sequencing which base on SNPs have made a great progress in identifying cancer susceptibility.The development and application of high resolutions in SNPs has played an important role in clarifying the mechanism,prevention,diagnosis and targeted therapy in cancers.
