Clinical analysis of 4 cases of amyotrophic lateral sclerosis concomitant with Sj(o)gren' s syndrome

VernacularTitle:肌萎缩侧索硬化伴干燥综合征四例临床分析
Author: Qin LIAO ; Dongsheng FAN
Publication Type:Journal Article
Keywords: Amyotrophic lateral sclerosis; Sj(o)gren's syndrome; Motor neuron disease; Electrophysiology
From: Chinese Journal of Neurology 2012;45(7):467-470
CountryChina
Language:Chinese
Abstract: Objective To describe the clinical characteristics of 4 patients with concomitant amyotrophic lateral sclerosis (ALS) and Sj(o)gren' s syndrome.Methods The clinical features,laboratory findings,and electrophysioiogical manifestations etc.of these patients were analyzed.Results Four female patients all developed progressively aggregated weakness in their limb/limbs at the fifth to sixth decades of their lives.According to their neurologic findings,3 met the criteria of clinical probable ALS,while the other was diagnosed with probable laboratory-supported ALS.All these patients showed diffused patterns of neurogenic changes in electromyography tests.Motor symptoms of 2 patients transiently improved after immunomodulation treatments.Conclusion Careful screening of the Sj(o)gren' s syndrome symptoms in patients with ALS is necessary so as to deal with the treatable concomitant disease in time.