The potential role of miR-146a in the pathogenesis and diagnosis of autoimmune diseases
10.3760/cma.j.issn.1009-9158.2012.03.003
- VernacularTitle:miR-146a在自身免疫性疾病发病机制及临床诊疗研究中的进展
- Author:
Tingting JIA
;
Lunan WANG
- Publication Type:Journal Article
- Keywords:
Autoimmune diseases;
MicroRNAs;
Arthritis,rheumatoid;
Lupus erythematosus,systemic
- From:
Chinese Journal of Laboratory Medicine
2012;35(3):202-206
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA(miR),a type of 22nt non-coding RNA,modulate gene expression at posttranscriptional level by interacting with targeting mRNA and play an important role in both inflammatory reaction and autoimmune diseases.Especially,the expression of miR-146a in autoimmune diseases has gotten more and more attention in recent studies.This review summarized the correlation between the expression of miR-146a and the pathogenesis of some common autoimmune diseases.What's more,the potential role of miR-146a in the clinical diagnosis of autoimmune diseases are also discussed.
