Clinical analysis of maintenance hormonal treatment for patients with advanced breast cancer after response to chemotherapy
10.3760/cma.j.issn.1006-9801.2011.09.007
- VernacularTitle:化疗有效后内分泌维持治疗晚期乳腺癌八例临床分析
- Author:
Xueli MO
;
Delin WANG
;
Yujuan CAO
;
Fang DU
;
Jianhua SUN
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Maintenance therapy;
Chemotherapy;
Endocrine therapy
- From:
Cancer Research and Clinic
2011;23(9):598-599
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the efficacy of maintenance hormonal treatment after response to chemotherapy in advanced breast cancer. Methods8 patients with advanced breast cancer were treated with chemotherapy,maintenance hormonal therapy were given after response to chemotherapy.The efficacy was evaluated every 2 cycles of chemotherapy and 2 months of endocrine therapy according to RECIST standard.Results8 patients received chemotherapy for 2-8 cycles (median 4 cycles). All patients got PR, the duration of chemotherapy was 1-6 months (median 2 months), the time to failure of chemotherapy was 4 months. Until the last follow-up day (31th December 2010), the time to progression was 6-86 months (median 13.5 months).Survival was 6-86 months(median 21.5 months).Seven patients quit the chemotherapy due to severe side effects of hematologic toxicity,fatigue or nausea vomiting.One patient died because of allergy to paclitaxol.Conclusion Maintenance hormonal treatment after patients with metastatic breast cancer response to chemotherapy may prolong the duration of effective therapy and improve the QOL.
