Clinical observation on compound matrine combined with intensity modulation radiotherapy in the treatment of local advanced nasopharyngeal carcinoma
10.3760/cma.j.issn.1006-9801.2011.09.015
- VernacularTitle:复方苦参注射液联合适形调强放疗治疗局部晚期鼻咽癌的临床观察
- Author:
Zetian SHEN
;
Xinhu WU
;
Bing LI
;
Xixu ZHU
- Publication Type:Journal Article
- Keywords:
SOPHORA FLAVESCENS;
Radiotherapy, computer-assisted;
Nasopharyngeal neoplasms
- From:
Cancer Research and Clinic
2011;23(9):623-625
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo detect the efficacy of compound matrine combined with intensity modulated radiotherapy (IMRT) for patients with locally advanced nasopharyngeal carcinoma (NPC). MethodsA total of 96 patients with locally advanced NPC were randomized into compound matrine combined with IMRT group (the therapeutic group) (n =48) and IMRT group (control group) (n =48). The nasopharyngeal DT and lymph nodes Dr were 66-78 Gy/(33-39 f)in 6-8 weeks,60-70 Gy/(30-35 f)in 6-8 weeks, respectively.The prophylactic dose of neck was 50-54 Gy.ResultsThe NPC efficacy of the therapeutic group was 93.8 ％(45/48)and control group was 79.2 ％(38/48).There was significant difference between the two groups in curative effect (P ＜0.05). The lymph nodes efficacy of the therapeutic group was 87.5 ％ (44/48) and control group was 75.0 ％ (30/48). There was significant difference between the two groups in curative effect (P ＜0.05). The side effects of mucosa were fewer in therapeutic group while the infection rate of pharynx oralis was higher in control group (P ＜0.01). ConclusionCompound matrine combined injection can improve shortterm curative effect of IMRT of locally advanced NPC and significantly decreased side effect of radiotherapy.
