The impact of type 2 diabetes on endothelium of great saphenous vein in patients with coronary heart disease
10.3760/cma.j.issn.1001-4497.2011.08.011
- VernacularTitle:2型糖尿病对冠心病患者大隐静脉旁路血管内皮细胞的影响
- Author:
Shikang LI
;
Zhengkun LI
;
Cun LONG
;
Lishu HE
;
Qiyun ZHOU
;
Yingxue HU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,non-insulin-dependent;
Coronary artery disease;
Great saphenous vein;
Endothelium;
Coronary artery bypass
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2011;27(8):480-482
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the impact of type 2 diabetes mellitus on endothelium of great saphenous vein in patients with coronary heart disease.MethodsPatients undergoing coronary artery bypass grafting were selected, 20 with type 2 diabetes mellitus (experimental group) and another 20 patients without (control group).The rings of great saphenous vein in I cm length were taken from those patients and then divided into 3 segments.The structure of endothelium was evaluated by the microscope and the changes of venous tone were measured in organ chamber at 37C with a constant supply of oxygen.Venous vasoconstriction was induced by phenylephrine (10-5 mol/L) and vasodilatation induced by nitroglycerin or acetylcholine (10-9 ～ 10-5 mol/L).ResultsMore damages of ultrastructure of the endothelium of saphenous vein were found in experimental group than in control group.There were no significant differences regarding the venous tone between the two groups (P ＞0.05) when vasoconstriction induced by phenylephrine and vasodilatation by nitroglycerin.However, the vasodilatation induced by acetylcholine was significantly decreased in experimental group than in control group (P ＜ 0.05).Conclusion Type 2 diabetes mellitus can aggravate the damage of endothelium of saphenous vein in patients with coronary artery disease.
