Study on p53 codon 72 polymorphism in patients with breast cancer
10.3760/cma.j.issn.1006-9801.2011.09.027
- VernacularTitle:p53基因多态性与乳腺癌的相关性研究进展
- Author:
Xiaoying ZHOU
- Publication Type:Journal Article
- Keywords:
Genes,p53;
Breast neoplasms;
Therapy;
Prognosis
- From:
Cancer Research and Clinic
2011;23(9):646-648
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is the most frequent malignant tumors in women,The p53 gene is found to be one of the most closely associated tumor-suppressor genes in human malignant tumors.Some studies have shown an association between polymorphisms at the forth exon (codon 72) and human malignancies recently.At present, the domestic investigations concerned the p53 polymorphisms mainly in lung cancer, uterocervical cancer,esophagus cancer,ovarian cancers,but the studies in breast cancer are rare in domestic.The correlation between the genotypes of p53 codon 72 polymorphism and breast cancer were reported.
