The correlation between P300 and Loewenstein's occupational therapy cognitive assessment for patients with stroke
10.3760/cma.j.issn.0254-1424.2011.07.010
- VernacularTitle:脑卒中患者P300与洛文斯顿认知评定量表相关性研究
- Author:
Shiyan WANG
;
Zunke GONG
;
Wei CHEN
;
Ming ZHANG
- Publication Type:Journal Article
- Keywords:
Stroke;
Cognitive impairment;
Event-related potentials;
Loewenstein's occupational therapy cognitive assessment
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2011;33(7):518-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between P300 and Loewenstein occupational therapy cognitive assessment (LOTCA) results, and to analyze its clinical significance. Also to explore whether P300 might represent specific cognitive functions. Methods Sixty stroke patients were matched with 30 healthy persons serving as a control group. All were examined with auditory evoked potential P300 and the LOTCA, and the correlation between the results was analyzed.Results The stroke patients had significantly longer P200,N200 and P300 latencies and significantly lower P300 amplitude compared with the controls. The LOTCA total scores and each sub-item score in the patient group were all significantly lower than those in the control group. In the patient group, there was strong negative correlation between P300 latency and the total LOTCA score, weak positive correlation between P300 amplitude and the total LOTCA score, and medium to high negative correlation between P300 latency and LOTCA sub-item scores. Stepwise regression and multivariate analysis revealed that sub-items of LOTCA, followed by thinking operations, motor praxis and spatial perception, were strongly correlated with P300 latencies.Conclusions Significant correlation were found between P300 and LOTCA. The combination of P300 and LOTCA can enable earlier, more objective and more comprehensive assessment of vascular cognitive impairment. The latency of P300 has no obvious specificity in reflecting cognitive function, and it is affected by thinking operations most.
