Observation of oral pharynx pain treated with durogesic in malignant tumor patients during radiochemotherapy
10.3760/cma.j.issn.1006-9801.2011.08.013
- VernacularTitle:芬太尼透皮贴剂治疗恶性肿瘤放化疗相关性口咽疼痛的疗效观察
- Author:
Haiyan QIN
;
Daoli NIU
;
Rong LI
;
Minghui WAN
;
Changbin JIANG
;
Wei YI
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Fentaryl;
Radiotherapy,computer-assisted;
Antineoplastic combined chemotherapy protocols;
Mouth;
Pharynx;
Pain
- From:
Cancer Research and Clinic
2011;23(8):545-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and adverse reaction of Durogesic (thansdermal fenfanul) for analgesia in patients with malignant tumors, who occur moderate or severe pain from mucosal response during radiochemotherapy. Methods 50 patients were divided into two groups randomly. The treatment group received Durogesic and normal therapy, the contrast group received normal therapy. The analgesic effects, the quality of life and the side effects after medicine were observed. Results The pain remission rates of treatment group and control group were 100 % (25/25) and 52 % (13/25), respectively (χ2 =15.78, P ＜ 0.01)[(9.66±0.35), (10.01±0.34) min]and[(18.12±0.46), (14.68±0.19) min].The quality of life in treatment group was improved significantly (t = 8.11, P ＜0.01).The main adverse reactions of Durogesic included constipation, itch of skin, drowsiness, nausea, vomiting and so on. All of adverse reactions were tolerable. Conclusion Durogesic for analgesia have high curative effect and slight adverse effects in pain of oral cavity and laryngeal pharynx in patients with malignant tumors during radiochemotherapy which make patients complete radiochemotherapy successfully.
