P-glycoprotein expression in lung cancer and progress in cisplatin resistance

VernacularTitle:P-糖蛋白表达与肺癌顺铂耐药的研究进展
Author: Huang DAN
Publication Type:Journal Article
Keywords: Lung neoplasms; Glycoproteins; Cisplatin; Drug resistance,neoplasms
From: Cancer Research and Clinic 2011;23(8):565-567
CountryChina
Language:Chinese
Abstract: Cisplatin is widely used in lung cancer chemotherapy, but drug resistance seriously affects its efficacy.The mechanism of cisplatin resistance is not yet clear.Now it is widely recognized that P-glycoprotein (P-glycoprotein, P-gp) expression is associated with cisplatin resistance. Inhibition of P-gp expression can overcome cisplatin resistance and improve the treatment efficacy.