The influence of proton pump inhibitors on incidence of bacteremia after endoscopic ultrasonography guided fine needle aspiration

VernacularTitle:术前应用质子泵抑制剂对内镜超声引导下细针穿刺所致菌血症发生率的影响
Author: Hongmin QI ; Na LI ; Nan GE ; Zhijun LIU ; Sheng WANG ; Siyu SUN
Publication Type:Journal Article
Keywords: Endoscopic ultrasonography; Bacteremia; Micropunctures; Proton pump inhibitor
From: Chinese Journal of Digestive Endoscopy 2011;28(7):380-382
CountryChina
Language:Chinese
Abstract: Objective To investigate whether preoperative proton pump inhibitor (PPI) would increase the risk of bacteremia after endoscopic ultrasonography guided fine needle aspiration (EUS-FNA).Methods Dogs were randomly divided into experimental group ( n = 8) to take 20mg of omeprazole orally twice a day for 3 days before EUS-FNA, and control group (n = 10) to take placebo.EUS-FNA was performed to puncture the pancreas, and blood was collected before and after the procedure for culture.Bacteremia incidence of the two groups were compared.Results Bacteria culture was positive in 11 edogse.After excluding contamination, 1 dog in experimental group and 3 in control group were authentical bacteremia.There was no significant difference on the incidence of bacteremia between 2 groups based on Fisher test ( P = 0.383).Conclusion Aplication of PPI before EUS-FNA is not likely to increase the incidence of bacteremia.