Surveillance for neuraminidase inhibitor resistance of seasonal H1N1 influenza A viruses isolated in Shenzhen during 2008 to 2009

VernacularTitle:深圳市2008-2009年A型H1N1季节性流感病毒神经氨酸酶抑制剂耐药性监测
Author: Xing Lü ; Chunli WU ; Fan YANG ; Xin WANG ; Shisong FANG ; Xiaowen CHENG
Publication Type:Journal Article
Keywords: H1N1; Neuraminidase inhibitor; Resistant
From: Chinese Journal of Microbiology and Immunology 2011;31(7):609-612
CountryChina
Language:Chinese
Abstract: Objective To analyze neuraminidase(NA) inhibitor resistance of seasonal H1N1 influenza A viruses isolated in Shenzhen during 2008 to 2009. Methods The NA gene of these viruses were sequenced. Phylogenetic analysis of the sequences was performed with Mega3. 1 software. Results In 2008, most isolates of the seasonal H1 N1 virus were susceptible to neuraminidase inhibitors, but the H275Y mutation in the neuraminidase gene region associated with high-level oseltamivir resistance had been detected in 92.6% of the strains isolated in 2009. Furthermore, a strain with Q136K was found, which showed the resistance to Zanamivir. Conclusion In the light of emerging resistance, close monitoring and understanding of the nature and dynamics of resistance mutations in influenza virus should be a priority.