Expression of VEGF and VEGFR-2 in patients with operable advanced laryngeal cancer treated with induction chemotherapy

VernacularTitle:晚期喉癌患者血管内皮生长因子及其受体-2与诱导化疗预后的关系
Author: Jianling WANG ; Huifang ZHOU ; Xin WANG ; Haiyi YANG ; Zhe LI
Publication Type:Journal Article
Keywords: Laryngeal neoplasms; Vascular endothelial growth factor A; Drug therapy,combination; Prognosis
From: Cancer Research and Clinic 2011;23(8):548-550
CountryChina
Language:Chinese
Abstract: Objective To assess the prognostic values of the immunohistochemical expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) in a cohort of patients with operable advanced laryngeal cancer who have been treated with induction chemotherapy. Methods VEGF and VEGFR-2 expression in the Forty-nine patients was quantified by an enzyme immunosorbent assay in a retrospective series.Results The moderate to high VEGF expression in 34 patients were found and low expression in 15 patients. VEGFR-2 expression was moderate to high in 31 patients and was low expression in 18. The probability of a complete response to induction chemotherapy was significantly higher in patients with none to low VEGF expression.Conclusion VEGF expression seems to be a significant predictor of complete response to induction chemotherapy.