A Case of Congenital Mature B Cell Lymphoblastic Leukemia.
- Author:
Myung Geun SHIN
1
;
Soon Pal SUH
;
Dong Wook RYANG
Author Information
1. Department of Clinical Pathology, College of Medicine, Seonam University, Namwon, Korea
- Publication Type:Case Report
- Keywords:
Congenital leukemia;
B cell
- MeSH:
Biopsy;
Bone Marrow;
Cell Differentiation;
Congenital Abnormalities;
Diagnosis;
Female;
Humans;
Leukocytosis;
Parturition;
Peroxidase;
Precursor Cell Lymphoblastic Leukemia-Lymphoma*;
Purpura;
Skin;
Sudan;
Thrombocytopenia
- From:Korean Journal of Clinical Pathology
1999;19(4):392-395
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The patient was a 1-day-old female with full term normal vaginal delivery. Petechiae and purpura were noted on body surface at birth. She did not have mongoloid face and hand-foot deformity. The skin nodules were bluish to slate-grey in color, and observed on all body surfaces. Hepatosplenomegaly was also noticed. Peripheral blood smear showed marked leukocytosis (109,400/microliter), thrombocytopenia (16,000/microliter) and leukoerythroblastosis. VDRL and TORCH tests were negative. The bone marrow was replaced by leukemic lymphoblasts. The normal hematopoietic cells were depleted. The leukemic lymphoblasts expressed markers of mature B cell differentiation, negative for Sudan black B, peroxidase, and positive for PAS (en bloc pattern) stain. Skin biopsy specimen showed diffuse infiltration of the leukemic cells. The diagnosis was congenital mature B cell lymphoblastic leukemia. This patient died at 7 days after birth.
