The behavioral improvements and mechanisms by ziprasidone early intervention in a rat model of posttraumatic stress disorder
10.3760/cma.j.issn.1674-6554.2012.10.002
- VernacularTitle:齐拉西酮早期干预对创伤后应激障碍模型大鼠行为的改善作用及机制
- Author:
Lei WANG
;
Fan YANG
;
Yihuan CHEN
;
Yuanhan BAI
;
Yuting QIAO
;
Zhengwu PENG
;
Qingrong TAN
- Publication Type:Journal Article
- Keywords:
Ziprasidone;
Posttraumatic stress disorder;
Phosphorylated extracellular signal-regulated-protein kinase;
Rat
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(10):869-871
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of ziprasidone on the behavior and the expression of pERK1/2 in posttraumatic stress disorder(PTSD) model rats.Methods 24 adult male SD rats weighing (200 ±20) g were randomly divided into four groups (n =6):control group,single prolonged stress and foot shock (SPS&S) group,ziprasidone group and ziprasidone + U0126 group.The fear response to environment,high alertness,and anxiety & depression behavior of rats were tested by the open field,elevated plus-maze,and the expression of pERK1/2 was measured by Western blot.ResultsIn open field test(OFT),the SPS&S group( (76.23 ± 54.76) cm for horizontal motion distance,(4.60 ± 1.14) for the number of entering central region) showed significant difference compared with control group ( (343.77 ± 74.22 ) cm,( 12.40 ± 3.36 ) ) or ziprasidone group ( ( 274.98± 83.56) cm,( 12.00 ± 2.92) ) (P ＜ 0.01 ),but showed no significant difference with ziprasidone + U0126 group ( ( 138.14 ± 41.98) cm,(5.00 ± 1.58) ) (P ＞ 0.05 ).The results of elevated plus maze (EPM) were in accordance with the results of OFT.The expression of pERK1/2 in SPS&S group and ziprasidone + U0126 group showed significant decrease when compared with control group or ziprasidone group (P ＜ 0.01 ).ConclusionZiprasidone can obviously improve fear response to environment,high alterness and anxiety & depression behavior of rats,and these effects of ziprasidone may be carried out by up-regulation the expression of pERK1/2.
