The diagnostic value of medial temporal volume change in Alzheimer's disease

VernacularTitle:颞叶内侧亚结构体积变化对阿尔茨海默病的诊断价值
Author: Tao WANG ; Shifu XIAO ; Xia LI ; Minjie ZHU ; Pei DING ; Huawei LING
Publication Type:Journal Article
Keywords: Alzheimer's disease; Temporal lobe; Entorhinal cortex; Diagnosis
From: Chinese Journal of Behavioral Medicine and Brain Science 2012;21(10):900-902
CountryChina
Language:Chinese
Abstract: ObjectiveTo study the metastructure volumes of medial temporal lobe in diagnosis the patients with Alzheimer's disease (AD) using 3 dimensional MRI.Methods23 AD patients according to DSM-Ⅳ criteria and 23 normal controls (NC) were examined with 3D-MRI.Hippocampus formation,amygdala,entorhinal cortex ( EC ),perirhinal cortex ( PC),and comu temporale were measured with 3D-MRI.ResultsSensitivity and specificity of diagnosis AD were 73.9％,97％ ( Hippocampus formation) ;39.1％,95.7％ (amygdala) ;73.9％,95.7％ (EC) ;95.7％,87.0％ (PC) and 34.8％,39.1％ ( cornu temporale).Overall discriminate function =cornu temporal × 3.887 + PC × 5.960 - EC × 0.074 + amygdale × 3.489 + hippocampus formation × 6.656- 22.449.Over-all-accuracy was 91.3％.ConclusionThe total volume of PC can better diagnosis the mild to moderate AD than other structure of medial temporal lobe.The changes of the medial temporal lobe volume could be used in diagnosis the patients with Alzheimer's disease.