A comparative study of brain iron deposition in schizophrenia with and without tardive dyskinesia
10.3760/cma.j.issn.1674-6554.2012.10.016
- VernacularTitle:伴迟发性运动障碍精神分裂症患者脑铁沉积的对照研究
- Author:
Fangbin CHEN
;
Mei JIN
;
Leping XU
;
Feifei ZHOU
;
Li WANG
;
Juying JI
- Publication Type:Journal Article
- Keywords:
Tardive dyskinesia;
Schizophrenia;
Brain;
Iron;
Magnetic resonance imaging
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(10):916-918
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the relationship between brain iron deposition and pathogenesis of tardive dyskinesia (TD) in schizophrenia.MethodsThe corrected phase (CP) of basal ganglia was measured in schizophrenia with TD( n=18) and without TD( n =18 ) using susceptibility weighted imaging MRI.Abnormal Involuntary Movement Scale (AIMS) was applied for clinical assessment of TD.ResultsAfter adjusting for age,sexual,and antipsychotic dosage,the mean CP of substantia nigra (SN) and caudate nucleus (CN) were significantly lower in schizophrenia patients with TD ( ( - 0.194 ± 0.040 ) rad,( - 0.089 ± 0.023 ) rad) than those without TD ( ( - 0.163 ± 0.033 ) rad,( - 0.076 ± 0.013 ) rad ; P =0.022,0.023 ).Lower mean CP in CN correlated with higher severity score of AIMS in TD patients ( r =- 0.468,P =0.034).Logistic regression analysis showed that the lower CP vaule in SN (β=-72.12,P=0.029) and CN(β=- 156.43,P=0.037),aging (β=0.379,P=0.042)were associated with the onset of TD.ConclusionThe results imply that the excess iron accumulation in basal ganglia may be associated with pathogenesis of TD in schizophrenia.
