Roles of galanin peptide in tumorigenesis and tumor progression

VernacularTitle:甘丙肽在肿瘤发生发展中的作用
Author: Yumei SUI ; Penghua FANG ; Mingyi SHI ; Ping BU
Publication Type:Journal Article
Keywords: Galanin; Neoplasms; Galanin receptors
From: Journal of International Oncology 2012;39(10):738-741
CountryChina
Language:Chinese
Abstract: Galanin is a peptide with wide-ranging effects,especially within the central,peripheral nervous system and endocrine system.Many tumors of neuroendocrine origin,and also an increasing number of non-neuroendocrine cancers,have been shown to express galanin and/or its receptors.Expression of galanin peptide has been detected in pheochromocytoma,squamous cell carcinoma,pituitary adenoma,gastrointestinal cancers and so on.Galanin peptide plays an important role in tumori-genesis and progression of many kinds of tumors.Therefore,studying the roles of galanin and its receptors are helpful for diagnosis and treatment of tumors.