BRAF oncogene in malignant melanoma
10.3760/cma.j.issn.1673-422X.2012.10.019
- VernacularTitle:BRAF癌基因在黑色素瘤中的研究
- Author:
Jing LI
;
Xiaojing KANG
- Publication Type:Journal Article
- Keywords:
Melanoma;
Proto-oncogene proteins B-raf;
Mutation
- From:
Journal of International Oncology
2012;39(10):781-783
- CountryChina
- Language:Chinese
-
Abstract:
BRAF gene has the highest mutation rate and plays an important role in the occurrence,development,invasion and metastasis of melanoma.The frequency of the mutation varies in different clinical phenotypes,clinical pathology classifications and stages of malignant melanoma,which indicate a certain association of BRAF gene with the growth and prognosis judgment in malignant melanoma.BRAF gene mutation is the new direction of treatment in malignant melanoma molecular target therapy.
