Recurrence prevention by embedding 5-FU microparticles on the cutting surface after hepatectomy for HCC
10.3760/cma.j.issn.1007-631X.2012.10.009
- VernacularTitle:肝创面植入氟尿嘧啶微粒预防肝细胞癌切除术后复发
- Author:
Tao ZHENG
;
Feng XIE
;
Jiamei YANG
;
Weifeng SHEN
;
Li GENG
;
Binghua DAI
;
Rongxi SHEN
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Chemotherapy cancer regional perfusion;
Hepatectomy;
Fluorouracil
- From:
Chinese Journal of General Surgery
2012;27(10):805-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate embedding 5-FU microparticles during operation after hepatectomy for small hepatocellular carcinoma to prevent recurrence. Methods A retrospective analysis on 184 patients was done.All patients received liver resection for HCC from 2007 Mar.to 2008 Mar.In 90 cases,5-FU releasing microparticles were embeded on liver cutting surface after the tumor was resected (group A).94 cases in which no micropaticles were given served as controls (group B).All patients had a single tumor( ≤5 cm) without visible vessel invasion. Results The postoperative disease-free survival ( DFS),and median period of DFS of group A vs.group B was 43 months vs 35 months.Postoperative DFS rates of 1-,2-and 3-year were 86％,76％ ％ and 64％ respectively in A group,while they were 77％,61％and 49％ respectively in B group ( x2 =4.77,P ＜ 0.05 ).In two groups the liver and kidney main function index( TB,ALB,ALT,BUN,Scr)on day 7 and postoperative complications were not statistically different (P ＞ 0.05 ). Conclusions Embeding 5-FU microparticle after hepatectomy for HCC could increase the postoperative DFS rates,and patients do not suffer from significant liver and kidney malfunctions.
