Inflammation: a key factor of gallbladder cancer
10.3760/cma.j.issn.1007-8118.2012.09.021
- VernacularTitle:炎症是影响胆囊癌的重要因素
- Author:
Zhixin WANG
;
Chang LIU
;
Peijun LIU
;
Kai QU
;
Yanzhou SONG
;
Jichao WEI
;
Lei ZHOU
;
Fandi MENG
;
Ruitao WANG
;
Jingyao ZHANG
- Publication Type:Journal Article
- Keywords:
Inflammation;
Tumor;
Gallbladder cancer
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(9):723-726
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies have suggested that various kinds of inflammatory factors can influence the formation and development of tumor cells.Researche has shown that gallbladder cancer is closely linked with local inflammation,which is a risk factor for the development of gallbladder cancer.It is widely known that cholecystitis is closely correlated with gallstones,and that bile obtained from patients with gallbladder cancer contains a large variety of bacteria,such as Salmonella typhi,Helicobacter,and Escherichia coli.It is proposed that the gallbladder may be the result of the joint action of inflammation with the bacterial flora.Similarly,the inflammatory “tumor infiltrating lymphocyte” (TIL)can be observed in the tumor and its surrounding tissues,and may also play a role in tumor growth and metastasis.However,detailed mechanisms about the relationship between inflammation and gallbladder cancer is still not clear.No specific anti-inflammatory drugs for gallbladder cancer have been developed. In the near future,anti inflammatory drugs may play a more important role in gallbladder cancer prevention and treatment.
