Therapeutic efficacy of paroxetine and influence on inflammatory markers in elderly acute myocardial infarction patients with anxiety and depression
10.3760/cma.j.issn.1674-6554.2012.09.018
- VernacularTitle:帕罗西汀对老年急性心肌梗死患者焦虑抑郁情绪及血清炎症标志物的影响
- Author:
Lizhen WANG
- Publication Type:Journal Article
- Keywords:
Acute myocardial infarction;
Elderly;
Anxiety;
Depression;
Inflammatory markers;
Paroxetine
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(9):823-825
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the therapeutic efficacy of paroxetine and influence on inflammatory markers in elderly acute myocardial infarction (AMI) patients with anxiety and depression.Methods 136 patients with AMI graded bythe hospital depression and anxiety score were divided into three class:(1)patients with anxiety ( n =54) ; (2)Patients with depression ( n =39) ; (3)Patients with anxiety and depression ( n =43 ).136 patients were randomly divided into paroxetine group (paroxetine 10-20 mg/d)and conventional group (conventional drugs based on guidelines).After 28 days treatment,HAD scores,serum level of inflammatory markers (Hs-CRP,MPO,and cTnI ) were compared between two groups.Results (1)HAD scores (HADa and HADd)of paroxetine group were decreased significantly after 28 days treatment (P ＜ 0.01 ) ;while there were no remarkable improvements in conventional group.With paroxetine treatment HAD scores of anxiety,depression,anxiety and depression( 10.52 ± 2.74,10.83 ±3.25,9.49 ± 2.57,9.99 ± 2.38) were much lower than those of conventional group(P ＜ 0.05 ).(2)Serum Hs-CRP,MPO and cTnI of paroxetine group in patients with anxiety were much lower than those of conventional group (P ＜ 0.05 ).Serum Hs-CRP,MPO and cTnI of paroxetine group in patients with depression were much lower than those of conventional group (P ＜ 0.05 ).Serum Hs-CRP,MPO and cTnI of paroxetine group in patients with anxiety and depression were much lower than those of Conventional group (P＜ 0.05 ).ConclusionParoxetine has remarkable treatment effect in elderly AMI patients with anxiety and depression,and paroxetine call significantly decreased serum levels of inflammatory markers.
