Experimental study on effects of captopril on renal perfusion in diabetes mellitus rabbits by contrast-enhanced ultrasound
10.3760/cma.j.issn.1004-4477.2012.09.021
- VernacularTitle:超声造影评价卡托普利对糖尿病兔肾血流灌注的影响
- Author:
Jian WANG
;
Chunsong KANG
;
Kailing SHI
;
Jiping XUE
;
Ruili WANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Captopril;
Diabetes mellitus;
Kidney;
Hemodynamic phenomena
- From:
Chinese Journal of Ultrasonography
2012;21(9):803-806
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of captopril on renal perfusion of diabetic mellitus(DM)rabbits at early stage by contrast-enhanced ultrasound (CEUS).Methods Of 58 rabbits,6 were control group,37 were made as DM model successfully by alloxan and were randomly divided into 4 groups:untreatment group (n =16) and treatment group A,B and C (n =7 averagely).The treatment groups were given captopril(25 mg/kg weight) everyday by intragastric administration after the DM model established and renal pathology appeared Mogensen DN Ⅰ,Ⅱ or / and Ⅲ respectively.The treatment lasted 12 week.Then CEUS was performed on bilateral kidney to observe the renal perfusion,the parameters included:curve ascending slope(K1),time to peak intensity(PIT),peak signal intensity(PSI),area under the curve(AUC) and time to half of peak intensity(HPT).Results At the end of 12 weeks,compared with control group,PIT and HPT delayed,PSI and K1 decreased in untreatment group and group C,AUC of untreatment group increased.Compared with untreatment group,PIT,HPT and AUC decreased,PSI and K1 increased in group A,B and C.Compared with group C,HPT of treatment group A,B decreased.Compared with control group,renal's size increased and the cortex was thickened in untreatment group and group A,B,C.The pathological examination showed:renal were damaged more seriously in untreatment group than that in group A and B.There was no significant difference in Scr and BUN between all groups.Conclusions Assessment of CEUS for renal perfusion of diabetic mellitus rabbits at early stage is feasible and captopril can improve renal perfusion of DM rabbits.
