Glycolysis abnormality in neoplasm cells and the targeted therapy
10.3760/cma.j.issn.1673-422X.2012.10.002
- VernacularTitle:肿瘤细胞的糖酵解异常及靶向治疗
- Author:
Yuyang PANG
;
Ting WANG
;
Fangyuan CHEN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Glycolysis;
Therapies
- From:
Journal of International Oncology
2012;39(10):726-728
- CountryChina
- Language:Chinese
-
Abstract:
Cancer cells display a decreased mitochondrial respiration along with an abnormal activation of glycolysis to satisfy the demand of the malignant growth even in the presence of oxygen.This phenomenon may be caused by mitochondrial dysfunction,hypoxia of microenvironment and the abnormal activation of upstream regulators of glycolysis pathway.Treatment targeted at the glycolysis pathway and its upstream regulators may provide a new therapeutic strategy of cancer.
