Contrast-enhanced ultrasound in the assessment of renal cortical perfusion in rabbits in low temperature conditions
10.3760/cma.j.issn.1004-4477.2012.09.022
- VernacularTitle:超声造影评价低温条件下兔肾皮质血流灌注变化
- Author:
Baojie WEN
;
Junying CAO
;
Yun ZHANG
;
Zhihong LI
;
Lihua LI
;
Yulei LIU
;
Wenying CHEN
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Kidney cortex;
Hypothermia;
Hemodynamic phenomena
- From:
Chinese Journal of Ultrasonography
2012;21(9):807-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of contrast-enhanced ultrasound(CEUS) in the evaluation of the renal cortical perfusion in rabbits in low temperature conditions.Methods 20 New Zealand rabbits were randomly divided into five groups,4 rabbits in each group:1) with the first group as the control group (under the conditions of room temperature) ; 2)The second group was treated under-15℃--23℃ for 8hours; 3)the third group was treated under-15℃--23℃ for 4 hours; 4)the fourth group was treated under-6℃--14℃ for 8 hours; 5) the fifth group was treated under-6℃--14℃ for 4 hours.SonoVue was injected via the ear vein at a dose of 0.1 ml/kg,the renal perfusion imaging was made,observing the dynamic image of 0-3 min after the injection and analyzing the time-intensity curves(TIC)obtained from the following parameters:the slope rate of ascending curve(A),the slope rate of descending curve(α),area under the curve (AUC),time to peak (TTP),and derived peak intensity(DPI).Results Compared with the control group,the A,α of the second and the fourth group were significantly decreased (P ＜ 0.05),while the AUC was significantly increased (P ＜ 0.05) and the TTP was significantly prolonged(P ＜0.05),for the third and the fifth group,only the A was decreased (P ＜0.05),and the DPI in each group showed no significant difference.Compared with the third and the fourth group,the AUC of the second group was increased and the TTP was prolonged (P ＜0.05).Conclusions Contrast-enhanced ultrasound can reflect the earlier renal cortical hemodynamic changes in rabbits in the low-temperature conditions,and is of great value for the early diagnosis of renal damage caused by low temperature.
