Expression and clinical significance of Survivin and COX-2 in human ampullary carcinoma
10.3760/cma.j.issn.1673-422X.2012.09.022
- VernacularTitle:Survivin和环氧合酶-2在壶腹癌中的表达及临床意义
- Author:
Dong XUE
;
Kai ZUO
;
Xinjun LI
;
Jianqiang WANG
;
Chengde ZHANG
;
Piguang CHENG
;
Tongjun ZHANG
;
Bengang GONG
- Publication Type:Journal Article
- Keywords:
Ampulla of vater;
Neoplasms;
Survivin;
Cyclooxygenase 2;
Immunohischemistry
- From:
Journal of International Oncology
2012;39(9):713-717
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Survivin and COX-2 in ampullary carcinoma and their clinical significance.MethodsThe expression of Survivin and COX-2 proteins were tested by EnVision immunohistochemistry in 40 cases of ampullary carcinomas,and 8 cases of normal ampulla of vater as the controls.ResultsThe positive rate of Survivin in ampullary carcinonas was significantly higher than that of the controls(82.5％ vs 0,P ＜ 0.01 ). The expression of Survivin in ampullary carcinoma was correlated with duodenal invasion,pancreatic invasion and lymph node metastasis ( P ＜ 0.05 ).Significant difference was also observed in the expression rate of COX-2 between the patients with ampullary carcinoma and the normal controls (67.5％ vs 0,P ＜ 0.01 ).The expression of COX-2 in ampullary carcinoma was correlated with duodenal invasion,pancreatic invasion and lymph node metastasis (P ＜ 0.05). Significantly positive correlation was found between the expression of Survivin and COX-2 by using spearman correlation analysis ( r =0.383,P =0.015).ConclusionThe specific up-regulation of COX-2 gene and Survivin gene may play an important role in the genesis and development of ampullary carcinoma.COX-2 and Survivin may be used as early diagnosis markers and potential therapeutic targets in ampullary carcinoma.
