Cucurmosin induced the apoptosis of pancreatic cancer cell SW1990 via EGFR signaling pathway
10.3760/cma.j.issn.1007-8118.2012.09.014
- VernacularTitle:南瓜蛋白经表皮生长因子受体信号通路诱导人胰腺癌细胞SW1990凋亡
- Author:
Baoming ZHANG
;
Heguang HUANG
;
Jieming XIE
;
Minghuang CHEN
;
Congfei WANG
;
Qiang YIN
;
Aiqin YANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Cucurbita;
Apoptosis
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(9):700-703
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanisms involved in cucurmosin-induced apoptosis of pancreatic cancer cell SW1990.Methods The expression of EGFR,PI3K,Akt,Bad,Caspase -9,mTOR,P70S6K-α,and 4E BP1 at the protein level were detected by western blot analysis,and RTPCR was used to determine EGFR mRNA expression.Results An increased concentration of cucurmosin showed a subsequent decrease in the expression of EGFR,PI3K,Akt,mTOR,P70S6Kα,and 4E -BP1,whereasthe expression of Bad and Caspase-9 were elevated.However,the mRNA expression of EGFR was unchanged.Conclusion Cucurmosin is shown to induce the apoptosis of pancreatic cancer cell SW1990 by down regulating the expression of EGFR and thus inactivating the PI3K/Akt/mTOR signaling pathway.
