Problem and correction of the application of foreign instrument with higher false-positive prenatal screening for neural tube defects
10.3760/cma.j.issn.1673-4904.2012.27.004
- VernacularTitle:应用外国仪器产前筛查神经管缺陷假阳性偏高的问题及纠正
- Author:
Hairong ZHANG
;
Ke CHEN
;
Juan TIAN
;
Min ZHANG
;
Man ZHANG
- Publication Type:Journal Article
- Keywords:
Neural tube defects;
Multiple of the median;
Gestational age correction;
Maternal weight correction
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(27):11-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish appropriate correction models of serum marker α -fetoprotein (AFP) multiple of the median (MOM) for prenatal screening on patients with neural tube defect (NTD) at the second trimester to replace the foreign data currendy used in Beijing with a higher sensitivity.Methods A sample of 5815 mid-gestation pregnant women with normal pregnancy outcome were selected including 5557 cases of age ＜ 35 years and 258 cases of age ≥35 years.The regression relationship between AFP median and gestational age was builded by exponential model and the regression relationship between MOM and weight was builded by power model in age ＜ 35 years.The regression relationship between AFP median and gestational age was builded by S model and the regression relation ship between MOM and weight was builded by quadratic model in age ≥35 years.The normal reference values in two age sections were estimated approximately by percentiles method.Results Corrected AFP MOM values with mean value (age ＜ 35 years:1.001; age ≥35 years:1.113) and median value (age ＜ 35 years:0.934;age ≥35 years:0.990) obtained by regression analysis were more close to 1.00 than the data from the software[mean value(age ＜ 35 years:1.164; age ≥35 years:1.254) and median value (age ＜35 years:1.093; age ≥35 years:1.149)].There were significant differences (age ＜35 years:t =65.120,P =0.000;age ≥35 years:t =9.812,P =0.000).Conclusion Correction model for maternal serum marker is more applicable for Beijing population at the second-trimester prenatal screening.
