Expression and significance of bone sialoprotein and matrix metalloproteinase-9 in calcified metral valves of rheumatic heart disease

VernacularTitle:骨唾液蛋白和基质金属蛋白酶-9在风湿性心脏病瓣膜的表达及意义
Author: Chuanming BAI ; Bin ZHANG ; Nan ZHANG ; Shutian SONG ; Zhigang ZHANG ; Yuqing BIAN ; Jiewu ZHOU
Publication Type:Journal Article
Keywords: Bone sialoprotein; Matrix metalloproteinase-9; Rheumatic heart disease
From: Clinical Medicine of China 2012;28(10):1056-1058
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and significance of bone sialoprotein and matrix metalloproteinase-9 in calcified mitral valves in patients with rheumatic heart disease.Methods A total of 150 mitral valves were divided into the rheumatic group (n =120) and the non-rheumatic group (n =30 ).Expressions of bone sialoprotein and matrix metalloproteinase-9 were determined by immunohistochemistry.Results Expressions of bone sialoprotein ( 91.6％,x2 =56.6354 ) and matrix metalloproteinase-9 ( 90.8％,x2 =59.4272) in the rheumatic group increased significantly than in the non-rheumatic group (P ＜ 0.01).Conclusion Both bone sialoprotein and matrix metalloproteinase-9 are highly expressed in the calcified rheumatic group.This suggests that caficify of rheumatic mitral valves is related with the degradation and remodeling of extra cellular matricx by matrix metalloproteinase-9,as well as osteoblastlike bone formation by bone sialoprotein.