Clinical observation of pregabalin in the treatment of painful diabetic peripheral neuropathy
10.3760/cma.j.issn.1008-6315.2012.10.003
- VernacularTitle:普瑞巴林治疗痛性糖尿病周围神经病变的效果观察
- Author:
Hui ZHAO
;
Chong WANG
;
Lin ZHU
;
Xin ZHANG
- Publication Type:Journal Article
- Keywords:
Pregabalin;
Diabetes;
Diabetic peripheral neuropathy
- From:
Clinical Medicine of China
2012;28(10):1016-1019
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of pregabalin in the treatment of painful diabeticperipheral neuropathy.Methods In a 8-week study,50 patients were randomly assigned into two groups:the therapy group and the control group.The patients in the therapy group were treated with pregabalin 150 mg/d,and the patients in the control group were treated with carbamazepine 200 mg/d.The dose of pregabalin was increased to 300 mg/d till pain was alleviated in the therapy group,and the dose of carbamazepine was increased to 600 mg/d till pain was alleviated in the control group.The therapeutic effect and VAS score in the two groups were observed and evaluated.Results After 1 and 8 weeks' treatment,the therapeutic effect of therapy group were significantly superior to the control group ( At 1 week:U =2.028,P =0.046 ; At 8 week:U =3.540,P ＜0.001 ).After 1 and 8 weeks' treatment,the VAS scores of therapy group were significantly lower than the control group ( At 1 week:5.13 ± 1.76 vs.6.74 ± 1.52,P ＜ 0.05 ; At 8 week:1.13 ± 0.45 vs 3.27 ± 1.04,P ＜ 0.05).There were 5 patients (20％) and 10 patients (40％) had adverse reaction in the therapy and the control groups respectively.Conclusion Pregabalin is effective and safe for the treatment of painful diabetic peripheral neuropathy.
