Mitochondrial protein NDUFS3 and tumor
10.3760/cma.j.issn.1673-422X.2012.09.002
- VernacularTitle:线粒体蛋白NDUFS3与肿瘤
- Author:
Pei WANG
;
Xiaodong CHENG
;
Xing XIE
- Publication Type:Journal Article
- Keywords:
Mitochondria;
Neoplasms;
Proteins
- From:
Journal of International Oncology
2012;39(9):647-650
- CountryChina
- Language:Chinese
-
Abstract:
NDUFS3 is an essential subunit of mitochondrial NADH:ubiquinone oxidoreductase (complex Ⅰ ) and plays a critical role in the mitochondrial typeⅠ respiration chain.Mutations in this gene are shown to cause neurodegenerative disease such as Leigh syndrome (subacute necrotizing encephalopathy).In recent years,many evidences show that the expression of NDUFS3 proteins are lower in many cancerous cells compared to the corresponding normal cells.It comes to the conclusion that NDUFS3 may play a role in the tumorigenesis.
