Progress of renal voltage-gated chloride channel
10.3760/cma.j.issn.1673-4408.2012.05.013
- VernacularTitle:肾脏电压门控氯离子通道研究进展
- Author:
Jinli ZHAO
- Publication Type:Journal Article
- Keywords:
Voltage-gated chloride channel;
Kidney;
Dent's disease;
Bartter's syndrome
- From:
International Journal of Pediatrics
2012;39(5):477-479
- CountryChina
- Language:Chinese
-
Abstract:
Voltage-gated chloride channel (ClC) is a class of very important chloride ion channels in vivo,participating in the chloride ion transporter,cell volume regulation,cell control acidification and many pathological physiological process.The studies have found that ClC-K was related to dent disease,and ClC-5 was associated with bartter syndrome.This article mainly reviews ClC-type chloride ion channel classification,structure,regulation and distribution in the kidney,and summarizes the related diseases.
